Clinical Bioinformatician (to Yerevan)

About BostonGene

Since our inception in Boston in 2015, we've led the charge in oncology personal healthcare, offering an extensive array of diagnostic tools that empower clinical decisions and advance patient care. Our culture is our foundation—fueled by innovation, a commitment to transformation, and a team of authentic, driven individuals worldwide. At BostonGene, you'll find a community that's not just about the work but about making a difference, together. Join us to be a part of a future where your work contributes to transformative cancer treatments and shapes the lives of patients globally.

Position Summary

BostonGene is seeking a Clinical Bioinformatician to join our team. The Clinical Bioinformatician will be responsible for conducting quality control of samples received from the laboratory, performing analysis of tumor biology for further calculations, and providing support in compiling reports for molecular analysts. The successful candidate will play a crucial role in ensuring accurate and reliable results in clinical bioinformatics.

Job responsibilities

• Independently analyze next-generation sequencing data (whole-exome and whole-genome sequencing, RNA-seq, cfDNA processing) for comprehensive genomic profiling in clinical oncology.
• Support clinical reports assembly.
• Perform analysis of tumor biology using bioinformatics tools and algorithms to extract meaningful insights and facilitate further calculations.
• Perform quality control and analysis of different types of genomic events (somatic and germline variants, CNA, fusions, rearrangements), gene expressions and complex biomarkers.
• Work in Laboratory Information Management System, as well as work management and issue-tracking software.
• Launch pipelines for NGS data processing, implementing workflow languages.
• Collaborate with laboratory personnel to understand sample characteristics and provide necessary input for accurate analysis.
• Collaborate with molecular analysts to understand their reporting requirements and provide necessary support in compiling comprehensive and accurate reports.
• Ensure compliance with regulatory guidelines and maintain high data integrity and confidentiality standards.

Required qualifications

• Bachelor's or Master's degree in Biology, Biochemistry, Microbiology, Molecular Biology, Genetics, Bioinformatics, Biotechnology or other biological sciences.
• Proficiency in bioinformatics tools, software packages, and programming languages commonly used in the field, such as Python (including Pandas, Matplotlib, NumPy, Seaborn, Plotly, standard modules like io, re, os, requests) and R.
• Hands-on experience with standard NGS tools: BWA or BWA-MEM, STAR, GATK, Strelka, Ensembl VEP/ANNOVAR, DESeq2 or edgeR.
• Strong knowledge of common NGS and bioinformatics file formats: FASTQ, BAM, SAM, CRAM, VCF, BED, GTF/GFF, MAF, TSV/CSV, and QC reports (FastQC, MultiQC).
• Knowledge of databases used in clinical genomics (ClinVar, COSMIC, gnomAD, OncoKB).
• Experience in data analysis in Python, including data cleaning, manipulation, and visualization.
• Familiarity with genomic data visualization instruments - IGV, UCSC Genome browser.
• Experience with cloud data storage and computing systems will be a plus.
• Experience with machine learning will be a plus (Scikit-learn, TensorFlow, PyTorch).
• Experience with Linux environments, Bash scripting skills, and experience using Git for code version control.
• Strong understanding of molecular biology concepts and familiarity with genomic and transcriptomic data analysis techniques.
• Excellent analytical and problem-solving skills with the ability to interpret complex biological data and draw meaningful conclusions.
• Solid knowledge of data visualization techniques.
• Proficient in statistical methods, including differential expression analysis, multiple-testing control, association and survival modelling, and high-dimensional data exploration via clustering and dimensionality reduction.
• Strong attention to detail and the ability to work accurately in a fast-paced laboratory environment.
• Practical communication skills with the ability to collaborate with cross-functional teams and present findings to both technical and non-technical stakeholders.

Why Join Us?

Join our team at BostonGene, where your work makes a real difference! As a pioneering biotech company with a global footprint, we're passionate about improving lives through groundbreaking oncology personal healthcare. With a team of over 500 dedicated professionals, we foster an empowering environment where your unique skills contribute to a healthier, better world. At BostonGene, you're not just choosing a career; you're stepping into a role that leverages your talents to create a positive change. Discover a workplace that values you as its most precious asset, offering a competitive benefits package designed to enhance your life and those around you.

We offer:

• Full-time position with a permanent contract and flexible working hours, with hybrid work options.
• Competitive salary and comprehensive healthcare insurance.
• Convenient office location in Yerevan (1-minute walk from the metro) with on-site snacks.
• Relocation package for candidates and their immediate family members, including full documentation and bureaucracy support (bank accounts, residence permits, school contacts, etc.).
• Corporate benefits, including English language lessons and gym membership.
• Dynamic and versatile professional environment with a diverse team of bioinformaticians, biologists, physicians, and software developers committed to improving oncological healthcare.
• Careful, structured, and responsible supervision to support professional growth.